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Wilson Office of Naval Research, Boston Proceedings of the NATIONAL ACADEMY OF SCIENCES Volume 52, Number 2, August 15, 1964 Pearl did not state his definition of heavy smokers, nor specify what they smoked

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The effect of smoking appears to be complex than a mere reflection of patient stress.[19] Clarke et al

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Once use stops, the opposite effects are seen - this withdrawal is part of the reason nicotine is so addictive Nicotine indirectly causes the release of dopamine in the brain, which targets reward pathways

Claiming harm reduction as a business strategy Infiltrating scientific spaces is a key part of the industrys strategy, detailed in the 2019 Truth Initiative report Spinning a New Tobacco Industry, to recast its public image and protect its bottom line at the expense of public health